Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 10/20 | 0.63 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | CASP5 | P51878 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CASP4 | P49662 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2804551 | 0.89 | PPARG (0.80) | PPARGCASP1CASP5CASP4 | |
| SCHEMBL2807357 | 0.78 | PPARG (0.83) | PPARGCASP1CASP5CASP4 | |
| SCHEMBL2807168 | 0.78 | PPARG (0.83) | PPARGCASP1CASP5CASP4 | |
| SCHEMBL2805018 | 0.78 | PPARG (0.83) | PPARGCASP1CASP5CASP4 | |
| SCHEMBL2812228 | 0.77 | PPARG (1.00) | PPARGCASP1CASP5CASP4 | |
| SCHEMBL2805810 | 0.77 | PPARG (1.00) | PPARGCASP1CASP5CASP4 | |
| SCHEMBL2809044 | 0.77 | PPARG (1.00) | PPARGCASP1CASP5CASP4 | |
| SCHEMBL2807939 | 0.77 | PPARG (0.78) | PPARGCASP1CASP5KDM4ECASP4 | |
| SCHEMBL2805994 | 0.77 | PPARG (0.80) | PPARGCASP1CASP5ALDH1A1CASP4 | |
| SCHEMBL2806834 | 0.77 | PPARG (0.80) | PPARGCASP1CASP5MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046606-A1 | PYRIMIDINYL-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PPAR AGONISTS | SHANGHAI INSTITUTE OF MATERIA MEDICA, CAS (CN) | 2009-04-16 | — | — | WO | disclosed |