Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5604835 | 0.85 | — | — | |
| SCHEMBL1727188 | 0.83 | — | — | |
| SCHEMBL1188511 | 0.72 | KCNH2 (0.57) | NOS2KCNH2 | |
| SCHEMBL1186694 | 0.71 | KCNH2 (0.61) | KCNH2 | |
| SCHEMBL1188071 | 0.71 | KCNH2 (0.61) | KCNH2 | |
| SCHEMBL1187585 | 0.71 | KCNH2 (0.61) | KCNH2 | |
| SCHEMBL1187841 | 0.71 | KCNH2 (0.61) | KCNH2 | |
| SCHEMBL1188175 | 0.71 | KCNH2 (0.61) | KCNH2 | |
| SCHEMBL1187588 | 0.71 | KCNH2 (0.61) | KCNH2 | |
| SCHEMBL1187965 | 0.71 | KCNH2 (0.61) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |
| EP-2054414-A2 | IMIDAZOLE AMINES AS INHIBITORS OF BETA-SECRETASE | Wyeth (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008022024-A2 | IMIDAZOLE AMINES AS INHIBITORS OF BETA-SECRETASE | WYETH (US) | 2008-02-21 | — | — | WO | disclosed |
| CN-1420881-A | Beta-amino acid derivs. as inhibitors of matrix metalloproteases and TNF-alpha | BRISTOL MYERS SQUIBB PHARMACEU (US) | 2003-05-28 | — | — | CN | disclosed |
| CN-1272841-A | Novel lactam metalloprotease inhibitors | DU PONT PHARM CO (US) | 2000-11-08 | — | — | CN | disclosed |
| EP-0108380-B1 | PYRIDO 2,3-D PYRIDIMIN-5-ONES | STERLING DRUG INC. (US) | 1989-02-22 | — | — | EP | disclosed |
| EP-0095152-B1 | A PROCESS FOR PREPARING NICOTINONITRILES AND INTERMEDIATES USED THEREIN | STERLING DRUG INC. (US) | 1986-10-22 | — | — | EP | disclosed |
| US-4590194-A | 3-[methyl or dimethyl)amino]-6-(pyridinyl)pyridazines and their cardiotonic use | STERLING DRUG INC. (US) | 1986-05-20 | — | — | US | disclosed |
| EP-0150206-A4 | PYRIDINYL-2-PYRIMIDINAMINES USEFUL AS CARDIOTONICS AND PREPARATION THEREOF. | STERLING DRUG INC (US) | 1986-03-18 | — | — | EP | disclosed |
| EP-0150205-A4 | AD(PYRIDINYL)-2-PYRIMIDINYL BDUREAS USEFUL AS CARDIOTONICS AND PREPARATION THEREOF. | STERLING DRUG INC (US) | 1986-02-20 | — | — | EP | disclosed |
| US-4107315-A | 5-(Pyridinyl)-2(1H)-pyridinones | STERLING DRUG INC. (US) | 1978-08-15 | — | — | US | disclosed |
| US-4107167-A | Alkyl α-[3-(pyridyl)-anilinomethylene]acetoacetates | STERLING DRUG INC. (US) | 1978-08-15 | — | — | US | disclosed |
| US-4086233-A | ANTIALLERGENS | STERLING DRUG INC. (US) | 1978-04-25 | — | — | US | disclosed |
| US-4072746-A | CARDIOTONIC AGENTS | STERLING DRUG INC. (US) | 1978-02-07 | — | — | US | disclosed |
| US-4053475-A | ANTI-ALLERGIC AGENTS | STERLING DRUG INC. (US) | 1977-10-11 | — | — | US | disclosed |
| US-4032523-A | ANTIALLERGENS | STERLING DRUG INC. (US) | 1977-06-28 | — | — | US | disclosed |
| US-4018770-A | ANTIALLERGENS | STERLING DRUG INC. (US) | 1977-04-19 | — | — | US | disclosed |
| US-4008235-A | ANTIALLERGIC | STERLING DRUG INC. (US) | 1977-02-15 | — | — | US | disclosed |
| US-4004012-A | 3-Cyano-5-(pyridinyl)-2(1H)-pyridinones | STERLING DRUG INC. (US) | 1977-01-18 | — | — | US | disclosed |
| US-3992380-A | 5,8-Dihydro-5-oxo-2-(4-or 3-pyridinyl)pyrido[2,3-d]pyrimidine-6-carboxylic acids and esters | STERLING DRUG INC. (US) | 1976-11-16 | — | — | US | disclosed |