Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | GUSB | P08236 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3976760 | 0.95 | TSHR (0.52) | TSHRHTTLMNAGAKKDM4E | |
| SCHEMBL3977889 | 0.91 | TSHR (0.52) | TSHRHTTLMNAGAKKDM4E | |
| SCHEMBL3992613 | 0.89 | TSHR (0.52) | TSHRHTTLMNAGAKKDM4E | |
| SCHEMBL4829993 | 0.85 | TSHR (0.47) | TSHRHTTLMNAGAKKDM4E | |
| SCHEMBL4825278 | 0.85 | TSHR (0.47) | TSHRHTTLMNAGAKKDM4E | |
| SCHEMBL4830085 | 0.85 | TSHR (0.46) | TSHRHTTLMNAGAKKDM4E | |
| SCHEMBL4830082 | 0.84 | TSHR (0.44) | TSHRHTTLMNAGAKKDM4E | |
| SCHEMBL14279589 | 0.84 | TSHR (0.49) | TSHRHTTLMNAGAKKDM4E | |
| SCHEMBL4829994 | 0.84 | TSHR (0.49) | TSHRHTTLMNAGAKKDM4E | |
| SCHEMBL4824478 | 0.84 | TSHR (0.45) | TSHRHTTLMNAGAKKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009063364-A2 | MODULATORS OF UROTENSIN RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS INC. (US) | 2009-05-22 | — | — | WO | disclosed |
| WO-2009063364-A2 | MODULATORS OF UROTENSIN RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS INC. (US) | 2009-05-22 | — | — | WO | disclosed |
| WO-2009053895-A2 | QUINOLINE UROTENSIN-II RECEPTOR ANTAGONISTS | ENCYSIVE PHARMACEUTICALS INC. (US) | 2009-04-30 | — | — | WO | disclosed |
| WO-2009053895-A2 | QUINOLINE UROTENSIN-II RECEPTOR ANTAGONISTS | ENCYSIVE PHARMACEUTICALS INC. (US) | 2009-04-30 | — | — | WO | disclosed |