Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.58 |
| ▸ | AKT2 | P31751 | 4/20 | 0.51 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2573290 | 0.89 | AKT1 (0.59) | AKT1AKT2AKT3 | |
| SCHEMBL2576502 | 0.89 | AKT1 (0.59) | AKT1AKT2AKT3 | |
| SCHEMBL2576532 | 0.89 | AKT1 (0.59) | AKT1AKT2AKT3 | |
| SCHEMBL2573367 | 0.85 | AKT1 (0.58) | AKT1AKT2AKT3 | |
| SCHEMBL2575143 | 0.83 | AKT1 (0.77) | AKT1AKT2AKT3 | |
| SCHEMBL2579508 | 0.83 | AKT1 (0.77) | AKT1AKT2AKT3 | |
| SCHEMBL2573569 | 0.83 | AKT1 (0.77) | AKT1AKT2AKT3 | |
| SCHEMBL2573491 | 0.83 | AKT1 (0.77) | AKT1AKT2AKT3 | |
| SCHEMBL14330234 | 0.83 | AKT1 (0.77) | AKT1AKT2AKT3 | |
| Hydrochloric Acid SCHEMBL2573663 | 0.83 | AKT1 (0.76) | AKT1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054418-A1 | DIHYDROTHIENO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008006039-A1 | DIHYDROTHIENO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |