Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.62 |
| ▸ | MTOR | P42345 | 8/20 | 0.61 |
| ▸ | ATR | Q13535 | 12/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 10/20 | 0.50 |
| ▸ | PDCD1 | Q15116 | 10/20 | 0.50 |
| ▸ | ATRIP | Q8WXE1 | 10/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 10/20 | 0.50 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739897 | 0.82 | PIK3CA (0.72) | PIK3CAPIK3CDMTORATRCHEK1 | |
| SCHEMBL3076854 | 0.80 | PIK3CA (0.69) | PIK3CAPIK3CDMTORATRCHEK1 | |
| SCHEMBL3061831 | 0.79 | PIK3CA (0.81) | PIK3CAPIK3CDMTORATRCHEK1 | |
| SCHEMBL4529862 | 0.79 | PIK3CA (0.72) | PIK3CAPIK3CDMTORATRCHEK1 | |
| SCHEMBL738140 | 0.79 | PIK3CA (0.62) | PIK3CAPIK3CDMTORATRCHEK1 | |
| SCHEMBL2487510 | 0.79 | PIK3CA (0.62) | PIK3CAPIK3CDMTORATRCHEK1 | |
| SCHEMBL2487507 | 0.79 | PIK3CA (0.62) | PIK3CAPIK3CDMTORATRCHEK1 | |
| SCHEMBL3080008 | 0.78 | PIK3CA (0.60) | PIK3CAPIK3CDMTORATRCHEK1 | |
| SCHEMBL3597188 | 0.78 | PDCD1 (0.73) | PIK3CAPIK3CDMTORATRCHEK1 | |
| SCHEMBL11898393 | 0.78 | PDCD1 (0.73) | PIK3CAPIK3CDMTORATRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |