Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.56 |
| ▸ | MTOR | P42345 | 7/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3601671 | 0.88 | PIK3CA (0.56) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3594469 | 0.86 | PIK3CA (0.58) | PIK3CAPIK3CDMTORCYP3A4 | |
| SCHEMBL3609798 | 0.85 | PIK3CA (0.60) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3603952 | 0.85 | PIK3CA (0.58) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3596319 | 0.84 | PIK3CA (0.59) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3602677 | 0.84 | PIK3CA (0.61) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3601538 | 0.84 | PIK3CA (0.60) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3592694 | 0.84 | PIK3CA (0.58) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3598836 | 0.83 | PIK3CA (0.62) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3601014 | 0.83 | PIK3CA (0.58) | PIK3CAPIK3CDMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |