Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 20/20 | 0.59 |
| ▸ | HTR2C | P28335 | 13/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2064979 | 0.89 | HTR2A (0.75) | HTR2AHTR2CKCNH2 | |
| SCHEMBL2064472 | 0.82 | HTR2A (0.74) | HTR2AHTR2CKCNH2 | |
| SCHEMBL2063696 | 0.80 | HTR2A (0.46) | HTR2AHTR2C | |
| SCHEMBL884769 | 0.78 | HTR2A (0.76) | HTR2AHTR2CKCNH2 | |
| SCHEMBL884127 | 0.77 | HTR2A (0.80) | HTR2AHTR2CKCNH2 | |
| SCHEMBL883898 | 0.77 | HTR2A (0.79) | HTR2AHTR2CKCNH2 | |
| SCHEMBL883900 | 0.77 | HTR2A (0.79) | HTR2AHTR2CKCNH2 | |
| SCHEMBL2041276 | 0.77 | HTR2A (0.75) | HTR2AHTR2CKCNH2 | |
| SCHEMBL883989 | 0.76 | HTR2A (0.80) | HTR2AHTR2CKCNH2 | |
| SCHEMBL5055889 | 0.76 | HTR2A (0.74) | HTR2AHTR2CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018371-A1 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2009-01-28 | — | — | EP | disclosed |
| WO-2007136703-A1 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-29 | — | — | WO | disclosed |