⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL21248228 | 0.98 | TSHR (0.39) | — | |
| SCHEMBL11701161 | 0.93 | TSHR (0.40) | — | |
| SCHEMBL11557081 | 0.91 | EPHX1 (0.41) | — | |
| SCHEMBL11554271 | 0.91 | EPHX1 (0.41) | — | |
| SCHEMBL11549986 | 0.91 | EPHX1 (0.41) | — | |
| SCHEMBL11555891 | 0.91 | EPHX1 (0.41) | — | |
| SCHEMBL5413504 | 0.91 | EPHX1 (0.41) | — | |
| SCHEMBL11549970 | 0.91 | EPHX1 (0.41) | — | |
| SCHEMBL11553437 | 0.91 | EPHX1 (0.41) | — | |
| SCHEMBL11555439 | 0.91 | EPHX1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111699188-B | [1,2,4] triazolo [4,3-a ] pyrazin-8-one derivatives | 伊莱利利公司 | 2023-09-22 | — | — | CN | disclosed |
| EP-3749671-B1 | [1,2,4]TRIAZOLO[4,3-A]PYRAZIN-8-ONE DERIVATIVES | LILLY CO ELI (US) | 2023-03-29 | — | — | EP | disclosed |
| US-11453673-B2 | Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors | ELI LILLY AND COMPANY (US) | 2022-09-27 | — | — | US | disclosed |
| US-20200399277-A1 | [1,2,4]TRIAZOLO[4,3-A]PYRAZIN-8-ONE DERIVATIVES | ELI LILLY AND COMPANY | 2020-12-24 | — | — | US | disclosed |
| US-20200399277-A1 | [1,2,4]TRIAZOLO[4,3-A]PYRAZIN-8-ONE DERIVATIVES | ELI LILLY AND COMPANY | 2020-12-24 | — | — | US | disclosed |
| CN-111699188-A | [1,2,4] triazolo [4,3-a ] pyrazin-8-one derivatives | 伊莱利利公司 | 2020-09-22 | — | — | CN | disclosed |
| WO-2019156861-A1 | [1,2,4]TRIAZOLO[4,3-A]PYRAZIN-8-ONE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2019-08-15 | — | — | WO | disclosed |
| WO-2009058274-A1 | CHEMICAL MECHANICAL POLISHING AND WAFER CLEANING COMPOSITION COMPRISING AMIDOXIME COMPOUNDS AND ASSOCIATED METHOD FOR USE | EKC TECHNOLOGY, INC. (US) | 2009-05-07 | — | — | WO | disclosed |
| WO-2009058272-A1 | COPPER CMP POLISHING PAD CLEANING COMPOSITION COMPRISING OF AMIDOXIME COMPOUNDS | EKC TECHNOLOGY, INC. (US) | 2009-05-07 | — | — | WO | disclosed |
| WO-2009058278-A1 | METHODS OF CLEANING SEMICONDUCTOR DEVICES AT THE BACK END OF LINE USING AMIDOXIME COMPOSITIONS | EKC TECHNOLOGY, INC (US) | 2009-05-07 | — | — | WO | disclosed |
| US-4421693-A | INSECTICIDES, MITICIDES OR NEMATOCIDES | OTSUKA CHEMICAL CO., LTD. (JP) | 1983-12-20 | — | — | US | disclosed |
| US-4413005-A | 2,3-DIHYDRO-2,2-DIMETHYLBENZOFURAN-7-YL DERIVATIVES | OTSUKA KAGAKU YAKUHIN KABUSHIKI KAISHA (JP) | 1983-11-01 | — | — | US | disclosed |