Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.47 |
| ▸ | NR2E3 | Q9Y5X4 | 3/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 7/20 | 0.45 |
| ▸ | ADK | P55263 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.41 |
| ▸ | FLT1 | P17948 | 3/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | FLT4 | P35916 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3980027 | 0.84 | KDR (0.50) | PPARGNR2E3NCOR2KDM4EMCL1 | |
| SCHEMBL3982004 | 0.83 | KDR (0.52) | PPARGNR2E3NCOR2KDM4EMCL1 | |
| SCHEMBL3980068 | 0.82 | KDR (0.42) | PPARGNR2E3NCOR2KDM4EMCL1 | |
| SCHEMBL3976145 | 0.81 | RET (0.57) | PPARGNR2E3NCOR2KDM4EMCL1 | |
| SCHEMBL3978975 | 0.73 | KDR (0.47) | PPARGNR2E3NCOR2KDM4EMCL1 | |
| SCHEMBL3985507 | 0.73 | KDR (0.55) | PPARGNR2E3NCOR2KDM4EMCL1 | |
| SCHEMBL11492413 | 0.71 | ADORA1 (0.59) | PPARGNR2E3NCOR2KDM4EMCL1 | |
| SCHEMBL3985456 | 0.70 | KDR (0.45) | PPARGNR2E3NCOR2KDM4EMCL1 | |
| SCHEMBL3980741 | 0.70 | KDR (0.47) | KDRHPGDPTK2BCYP1A2CYP2C9 | |
| SCHEMBL3977506 | 0.69 | KDR (0.59) | PPARGNR2E3NCOR2KDM4EMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070032512-A1 | 6,6-Bicyclic ring substituted sulfur containing heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS, INC., | 2007-02-08 | — | — | US | claimed |
| US-7566721-B2 | Substituted thienol[2,3-d]pyrimidines as kinase inhibitors | OSI PHARMACEUTICALS, INC. (US) | 2009-07-28 | — | — | US | disclosed |
| US-20070032512-A1 | 6,6-Bicyclic ring substituted sulfur containing heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS, INC., | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032512-A1 | 6,6-Bicyclic ring substituted sulfur containing heterobicyclic protein kinase inhibitors | IGF1R, BRCA1, MAP2K6 | PPARG 2697/4885NR2E3 2850/4885NCOR2 1881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.