Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | CLK3 | P49761 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
| ▸ | F3 | P13726 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL995256 | 0.92 | IDO1 (0.46) | IDO1PDE3BPDE3AADORA2AADORA2B | |
| SCHEMBL995132 | 0.89 | PDE3B (0.44) | PDE3BPDE3AADORA2AADORA2BADORA1 | |
| SCHEMBL995648 | 0.87 | PDE3B (0.43) | PDE3BPDE3AADORA2AADORA2BADORA1 | |
| Hydrochloric Acid SCHEMBL994782 | 0.86 | PDE3B (0.42) | PDE3BPDE3AADORA2AADORA2BADORA1 | |
| SCHEMBL3792280 | 0.81 | PDE3B (0.49) | IDO1PDE3BPDE3AADORA2AADORA2B | |
| SCHEMBL12950973 | 0.76 | ADORA2A (0.40) | ADORA2AADORA2BADORA1CLK2DYRK1A | |
| SCHEMBL3799092 | 0.76 | PDE3B (0.55) | IDO1PDE3BPDE3AADORA2AADORA2B | |
| SCHEMBL3789858 | 0.76 | PDE3B (0.59) | PDE3BPDE3AADORA2AADORA2BADORA1 | |
| SCHEMBL20675714 | 0.76 | IDO1 (0.44) | IDO1PDE3BPDE3AADORA2AADORA2B | |
| SCHEMBL3796017 | 0.75 | PDE3B (0.46) | IDO1PDE3BPDE3AADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125804-A1 | 5-PHENYL-6-PYRIDIN-4-YL-1,3-DIHYDRO-2H-IMIDAZOÝ4,5-B¨PYRIDIN-2-ONE DERIVATIVES USEFUL AS A2B ADENOSINE RECEPTOR ANTAGONISTS | Almirall, S.A. (ES) | 2009-12-02 | — | — | EP | claimed |
| WO-2008080461-A1 | 5-PHENYL-6-PYRIDIN-4-YL-1,3-DIHYDRO-2H-IMIDAZO[4,5-B]PYRIDIN-2-ONE DERIVATIVES USEFUL AS A2B ADENOSINE RECEPTOR ANTAGONISTS | LABORATORIOS ALMIRALL, S.A. (ES) | 2008-07-10 | — | — | WO | claimed |