Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 12/20 | 0.64 |
| ▸ | EGFR | P00533 | 11/20 | 0.64 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | ACP1 | P24666 | 1/20 | 0.48 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.48 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.48 |
| ▸ | SSU72 | Q9NP77 | 1/20 | 0.48 |
| ▸ | CTSV | O60911 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.47 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4084764 | 0.92 | ERBB2 (0.66) | ERBB2EGFRGRM4AURKAACP1 | |
| SCHEMBL3979493 | 0.90 | EGFR (0.67) | ERBB2EGFRGRM4AURKAACP1 | |
| SCHEMBL3973068 | 0.84 | ERBB2 (0.62) | ERBB2EGFRGRM4AURKAACP1 | |
| SCHEMBL3973368 | 0.78 | ERBB2 (1.00) | ERBB2EGFRGRM4AURKA | |
| SCHEMBL27990835 | 0.76 | BCL6 (0.60) | EGFRAURKA | |
| SCHEMBL4084766 | 0.75 | ERBB2 (0.61) | ERBB2EGFRGRM4AURKA | |
| SCHEMBL1096310 | 0.75 | ERBB2 (1.00) | ERBB2EGFRGRM4AURKA | |
| SCHEMBL1105428 | 0.74 | EGFR (1.00) | ERBB2EGFRAURKA | |
| Diethylamine SCHEMBL4255489 | 0.74 | EGFR (0.89) | ERBB2EGFRAURKA | |
| SCHEMBL12172997 | 0.74 | PARP1 (0.61) | ERBB2EGFRACP1PTPN12PTPN13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009055299-A1 | SUBSTITUTED PYRIMIDINE-5-CARBOXAMIDE AND 5-CARBOXYLIC ESTER KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-30 | — | — | WO | claimed |
| WO-2009055299-A1 | SUBSTITUTED PYRIMIDINE-5-CARBOXAMIDE AND 5-CARBOXYLIC ESTER KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-30 | — | — | WO | disclosed |