Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 15/20 | 0.42 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974044 | 0.86 | SSTR5 (0.48) | SSTR5SSTR1HRH1HTR2B | |
| SCHEMBL3977776 | 0.83 | SSTR5 (0.50) | SSTR5HRH1HTR2B | |
| SCHEMBL3974073 | 0.78 | SSTR5 (0.51) | SSTR5SSTR1HRH1HTR2BSLC2A1 | |
| SCHEMBL2415829 | 0.78 | SSTR5 (0.54) | SSTR5SSTR1HRH1HTR2BLMNA | |
| SCHEMBL2418724 | 0.78 | SSTR5 (0.54) | SSTR5SSTR1HRH1HTR2BLMNA | |
| SCHEMBL3997426 | 0.76 | CYP3A4 (0.45) | SSTR5SSTR1HRH1HTR2BLMNA | |
| SCHEMBL27753757 | 0.74 | SSTR5 (0.50) | SSTR5SSTR1HRH1HTR2BLMNA | |
| SCHEMBL28782398 | 0.74 | SSTR5 (0.50) | SSTR5SSTR1HRH1HTR2BLMNA | |
| SCHEMBL3933800 | 0.72 | SSTR5 (0.44) | SSTR5SSTR1HRH1HTR2B | |
| SCHEMBL2419515 | 0.71 | SSTR5 (0.57) | SSTR5SSTR1HRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |