Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 12/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.49 |
| ▸ | NTRK2 | Q16620 | 8/20 | 0.47 |
| ▸ | SRC | P12931 | 4/20 | 0.47 |
| ▸ | INSR | P06213 | 3/20 | 0.47 |
| ▸ | LYN | P07948 | 3/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | ROS1 | P08922 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | FGR | P09769 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL395945 | 0.94 | NTRK1 (0.51) | NTRK1NTRK3NTRK2SRCKIT | |
| SCHEMBL396230 | 0.94 | NTRK1 (0.56) | NTRK1NTRK3NTRK2SRCKIT | |
| SCHEMBL393970 | 0.92 | NTRK1 (0.44) | NTRK1NTRK3NTRK2SRCINSR | |
| SCHEMBL393780 | 0.87 | NTRK1 (0.52) | NTRK1NTRK3NTRK2SRCKIT | |
| SCHEMBL397947 | 0.87 | NTRK1 (0.58) | NTRK1NTRK3NTRK2SRCKIT | |
| SCHEMBL399277 | 0.87 | TLK2 (0.47) | NTRK1RETAURKA | |
| SCHEMBL396159 | 0.87 | FLT3 (0.47) | NTRK1NTRK3NTRK2SRCINSR | |
| SCHEMBL396850 | 0.86 | NTRK1 (0.53) | NTRK1NTRK3NTRK2SRCKIT | |
| SCHEMBL399058 | 0.86 | FLT3 (0.48) | NTRK1KITMETPDGFRBFLT3 | |
| SCHEMBL394525 | 0.84 | FLT3 (0.51) | NTRK1NTRK3CSF1RKITPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101608-B2 | 3-(4-Methyl-imidazol-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide; including benign and malignant proliferative disorders as well as diseases resulting from inappropriate activation of the immune and nervous systems | IRM LLC, a Delware Limited Corporation (BM) | 2012-01-24 | — | — | US | claimed |
| US-8101608-B2 | 3-(4-Methyl-imidazol-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide; including benign and malignant proliferative disorders as well as diseases resulting from inappropriate activation of the immune and nervous systems | IRM LLC, a Delware Limited Corporation (BM) | 2012-01-24 | — | — | US | disclosed |