Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | TSHR | P16473 | 7/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | F2R | P25116 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973655 | 0.99 | SMN1; SMN2 (0.58) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 | |
| SCHEMBL2826602 | 0.93 | SMN1; SMN2 (0.57) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 | |
| SCHEMBL2826873 | 0.91 | SMN1; SMN2 (0.70) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 | |
| SCHEMBL2827567 | 0.91 | SMN1; SMN2 (0.56) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 | |
| SCHEMBL2826872 | 0.90 | SMN1; SMN2 (0.69) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 | |
| SCHEMBL2828631 | 0.88 | SMN1; SMN2 (0.55) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 | |
| SCHEMBL3984042 | 0.87 | SMN1; SMN2 (0.66) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 | |
| SCHEMBL2826848 | 0.86 | TSHR (0.64) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 | |
| SCHEMBL4998654 | 0.86 | SMN1; SMN2 (0.51) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 | |
| SCHEMBL18589275 | 0.86 | SMN1; SMN2 (0.53) | SMN1; SMN2TSHRLMNAHSD17B10OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057157-A2 | 2-AMIDO-4-ISOXAZOLYL THIAZOLE COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | Genentech, Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008022002-A2 | 2-AMIDO-4-ISOXAZOLYL THIAZOLE COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | GENENTECH, INC. (US) | 2008-02-21 | — | — | WO | disclosed |