Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 19/20 | 0.52 |
| ▸ | CDK2 | P24941 | 19/20 | 0.52 |
| ▸ | KDR | P35968 | 15/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3979909 | 0.85 | CDK1 (0.56) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL3985998 | 0.85 | CDK1 (0.62) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL3986948 | 0.84 | CDK1 (0.59) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL3983830 | 0.84 | CDK1 (0.67) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL3983696 | 0.81 | CDK1 (0.58) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL3982768 | 0.81 | CDK1 (0.58) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL3983691 | 0.80 | CDK1 (0.66) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL3983542 | 0.80 | CDK1 (0.63) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL3983314 | 0.77 | CDK1 (0.57) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL3983837 | 0.76 | CDK1 (0.67) | CDK1CDK2KDRCCNB1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059511-A1 | SULPHOXIMIDES AS PROTEIN KINASE INHIBITORS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008025556-A1 | SULPHOXIMIDES AS PROTEIN KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-06 | — | — | WO | disclosed |