Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL397242 | 0.94 | RET (0.45) | RETBTKKDM4EMAPTALDH1A1 | |
| SCHEMBL396429 | 0.90 | NTRK1 (0.40) | MAPTALDH1A1NTRK1NTRK3SRC | |
| SCHEMBL394153 | 0.89 | RET (0.45) | RETBTKKDM4EMAPTALDH1A1 | |
| SCHEMBL395939 | 0.88 | RET (0.49) | RETBTKKDM4EMAPTALDH1A1 | |
| SCHEMBL398744 | 0.87 | RET (0.53) | RETBTKNTRK1NTRK3ABL1 | |
| SCHEMBL397245 | 0.83 | MAPK14 (0.37) | NTRK1KDRFLT3MAPK14AURKB | |
| SCHEMBL393783 | 0.82 | RET (0.51) | RETBTKKDM4EMAPTALDH1A1 | |
| SCHEMBL4128689 | 0.81 | RET (0.55) | RETBTKKDM4EMAPTALDH1A1 | |
| SCHEMBL4128697 | 0.81 | RET (0.55) | RETBTKKDM4EMAPTALDH1A1 | |
| SCHEMBL393048 | 0.80 | RET (0.54) | RETBTKNTRK1NTRK3ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101608-B2 | 3-(4-Methyl-imidazol-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide; including benign and malignant proliferative disorders as well as diseases resulting from inappropriate activation of the immune and nervous systems | IRM LLC, a Delware Limited Corporation (BM) | 2012-01-24 | — | — | US | claimed |