Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | TOP1 | P11387 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HRAS | P01112 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | PRKCA | P17252 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3984912 | 0.96 | TOP1 (0.47) | SUV39H2CA1CA2TOP1ABL1 | |
| SCHEMBL31614523 | 0.93 | CA1 (0.53) | SUV39H2CA1CA2TOP1KDM4E | |
| SCHEMBL2072387 | 0.90 | CA1 (0.42) | SUV39H2CA1CA2TOP1ABL1 | |
| SCHEMBL3983639 | 0.89 | CA1 (0.45) | SUV39H2CA1CA2TOP1ABL1 | |
| SCHEMBL13845696 | 0.86 | HDAC1 (0.52) | SUV39H2TOP1ABL1PDGFRBSRC | |
| SCHEMBL3985524 | 0.85 | TOP1 (0.48) | SUV39H2CA1CA2TOP1ABL1 | |
| SCHEMBL25207597 | 0.85 | HDAC1 (0.55) | SUV39H2TOP1KDM4ENPC1RAB9A | |
| SCHEMBL13845729 | 0.85 | HDAC1 (0.55) | SUV39H2TOP1KDM4EHRASESR1 | |
| SCHEMBL14441950 | 0.84 | TOP1 (0.52) | SUV39H2CA1CA2TOP1KDM4E | |
| SCHEMBL25695184 | 0.84 | SUV39H2 (0.35) | SUV39H2CA1CA2TOP1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009060208-A1 | PYRROLOBENZODIAZEPINES | SPIROGEN LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |
| WO-2009060208-A1 | PYRROLOBENZODIAZEPINES | SPIROGEN LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |
| WO-2009060215-A1 | POLYAMIDES | SPIROGEN LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |
| WO-2009060215-A1 | POLYAMIDES | SPIROGEN LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |