Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.68 |
| ▸ | CDK1 | P06493 | 19/20 | 0.68 |
| ▸ | CDK2 | P24941 | 19/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3989071 | 0.89 | KDR (0.68) | KDRCDK1CDK2 | |
| SCHEMBL3983837 | 0.86 | CDK1 (0.67) | KDRCDK1CDK2 | |
| SCHEMBL3982310 | 0.85 | KDR (0.72) | KDRCDK1CDK2 | |
| SCHEMBL4592775 | 0.84 | KDR (0.79) | KDRCDK1CDK2 | |
| SCHEMBL4592768 | 0.84 | KDR (0.79) | KDRCDK1CDK2 | |
| SCHEMBL4592771 | 0.84 | KDR (0.79) | KDRCDK1CDK2 | |
| SCHEMBL4578234 | 0.81 | KDR (0.74) | KDRCDK1CDK2 | |
| SCHEMBL3932342 | 0.81 | CDK1 (1.00) | KDRCDK1CDK2 | |
| SCHEMBL3989069 | 0.81 | KDR (0.71) | KDRCDK1CDK2 | |
| SCHEMBL1776401 | 0.80 | KDR (0.69) | KDRCDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059511-A1 | SULPHOXIMIDES AS PROTEIN KINASE INHIBITORS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008025556-A1 | SULPHOXIMIDES AS PROTEIN KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-06 | — | — | WO | disclosed |