Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.57 |
| ▸ | KIT | P10721 | 4/20 | 0.57 |
| ▸ | KDR | P35968 | 3/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.57 |
| ▸ | LCK | P06239 | 2/20 | 0.57 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 8/20 | 0.44 |
| ▸ | AR | P10275 | 4/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2955295 | 0.88 | MAPK14 (0.71) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL395635 | 0.88 | MAPK14 (0.62) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL393368 | 0.81 | MAPK14 (0.46) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL4575830 | 0.80 | MAPK14 (0.52) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2954047 | 0.79 | MAPK14 (0.59) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2952626 | 0.79 | MAPK14 (0.59) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL396376 | 0.78 | MAPK14 (0.73) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL393973 | 0.78 | MAPK14 (0.73) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2954718 | 0.76 | MAPK14 (0.56) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2952034 | 0.73 | MAPK14 (0.49) | MAPK14KITKDRMAPK9LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101612-B2 | N-3-isoxazolyl-4-methyl-3-(1-((1-methylethyl)oxy)-6-phthalazinyl)benzamide; p38 kinase inhibitor; antiinflammatory, analgesic agent; rheumatoid arthritis, osteoporosis, leukemia, psoriasis, Crohn's disease, rhinitis, ulcerative colitis, dermatitis, asthma, Alzheimer's disease, type I and II diabetes | AMGEN INC. (US) | 2012-01-24 | — | — | US | claimed |
| EP-2077998-B1 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2011-03-09 | — | — | EP | disclosed |