Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.54 |
| ▸ | IKBKB | O14920 | 12/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3614907 | 0.78 | MAP3K7 (0.54) | MAP3K7IKBKBCHEK1 | |
| SCHEMBL3607420 | 0.74 | CHEK1 (0.74) | MAP3K7IKBKBCHEK1 | |
| SCHEMBL3608243 | 0.74 | IKBKB (0.55) | MAP3K7IKBKBCHEK1 | |
| SCHEMBL3612207 | 0.73 | MAP3K7 (0.62) | MAP3K7IKBKBCHEK1 | |
| SCHEMBL3612210 | 0.73 | CHEK1 (0.65) | MAP3K7IKBKBCHEK1 | |
| SCHEMBL3611798 | 0.72 | MAP3K7 (0.61) | MAP3K7IKBKBCHEK1 | |
| SCHEMBL3611804 | 0.71 | MAP3K7 (0.60) | MAP3K7IKBKBCHEK1 | |
| SCHEMBL1385004 | 0.71 | IKBKB (1.00) | MAP3K7IKBKBCHEK1HPGD | |
| SCHEMBL3842698 | 0.70 | MAP3K7 (1.00) | MAP3K7IKBKBCHEK1 | |
| SCHEMBL3608241 | 0.70 | IKBKB (0.55) | MAP3K7IKBKBCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572826-B2 | Thiophene-carboxamide derivatives and their use as inhibitors of the enzyme IKK-2 | ASTRAZENECA AB (SE) | 2009-08-11 | — | — | US | disclosed |