Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | TOP1 | P11387 | 2/20 | 0.37 |
| ▸ | HRAS | P01112 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4261257 | 0.86 | TOP1 (0.41) | MEN1KMT2ACSNK2A2CSNK2A1TOP1 | |
| SCHEMBL4093839 | 0.85 | ERBB2 (0.41) | MEN1KMT2ACSNK2A2CSNK2A1TOP1 | |
| SCHEMBL30944532 | 0.80 | NAMPT (0.42) | MEN1KMT2ATOP1HRASESR1 | |
| SCHEMBL30944502 | 0.80 | NAMPT (0.42) | MEN1KMT2ATOP1HRASESR1 | |
| SCHEMBL4275897 | 0.77 | HDAC1 (0.51) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL30944533 | 0.75 | CYP17A1 (0.41) | MEN1KMT2ATOP1HRASESR1 | |
| Hydrochloric Acid SCHEMBL30944564 | 0.75 | MEN1 (0.41) | MEN1KMT2ATOP1HRASESR1 | |
| SCHEMBL3984906 | 0.75 | TOP1 (0.41) | MEN1KMT2ATOP1HRASESR1 | |
| SCHEMBL30944554 | 0.75 | POLB (0.38) | MEN1KMT2ATOP1HRASESR1 | |
| SCHEMBL19633223 | 0.74 | NAMPT (0.43) | TOP1HRASESR1ESR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009060208-A1 | PYRROLOBENZODIAZEPINES | SPIROGEN LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |