Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 12/20 | 0.57 |
| ▸ | EGFR | P00533 | 4/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3982426 | 0.89 | CDK1 (0.57) | CDK1EGFRCDK2KDRGSK3B | |
| SCHEMBL3985388 | 0.86 | CDK1 (0.57) | CDK1EGFRCDK2KDRGSK3B | |
| SCHEMBL3982423 | 0.83 | CDK1 (0.58) | CDK1EGFRCDK2KDRGSK3B | |
| SCHEMBL3983830 | 0.76 | CDK1 (0.67) | CDK1CDK2KDR | |
| SCHEMBL3989071 | 0.74 | KDR (0.68) | CDK1CDK2KDR | |
| SCHEMBL3986948 | 0.71 | CDK1 (0.59) | CDK1CDK2KDR | |
| SCHEMBL3984145 | 0.71 | CDK1 (0.60) | CDK1EGFRCDK4MAPK3 | |
| SCHEMBL3985998 | 0.70 | CDK1 (0.62) | CDK1CDK2KDR | |
| SCHEMBL3989327 | 0.69 | CDK1 (0.67) | CDK1CDK2KDRCDK4 | |
| SCHEMBL15803830 | 0.69 | CDK1 (0.48) | CDK1EGFRCDK2KDRCDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059511-A1 | SULPHOXIMIDES AS PROTEIN KINASE INHIBITORS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008025556-A1 | SULPHOXIMIDES AS PROTEIN KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-06 | — | — | WO | disclosed |