Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 19/20 | 0.71 |
| ▸ | TNKS | O95271 | 1/20 | 0.65 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.65 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.65 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.65 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.65 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.65 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.65 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.65 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.65 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.65 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4248736 | 0.97 | PARP1 (0.67) | PARP1TNKSPARP6PARP15PARP14 | |
| SCHEMBL20544556 | 0.92 | PARP1 (0.66) | PARP1TNKSPARP6PARP15PARP14 | |
| SCHEMBL20544670 | 0.91 | PARP1 (0.66) | PARP1TNKSPARP6PARP15PARP14 | |
| Trifluoroacetic Acid SCHEMBL3922864 | 0.91 | PARP1 (0.61) | PARP1TNKSPARP6PARP15PARP14 | |
| Trifluoroacetic Acid SCHEMBL3990803 | 0.91 | PARP1 (0.62) | PARP1TNKSPARP6PARP15PARP14 | |
| SCHEMBL20544671 | 0.91 | PARP1 (0.63) | PARP1TNKSPARP6PARP15PARP14 | |
| Trifluoroacetic Acid SCHEMBL3986076 | 0.90 | PARP1 (0.62) | PARP1TNKSPARP6PARP15PARP14 | |
| SCHEMBL4252874 | 0.89 | PARP1 (0.78) | PARP1 | |
| SCHEMBL3989478 | 0.88 | PARP1 (0.64) | PARP1TNKSPARP6PARP15PARP14 | |
| SCHEMBL3982076 | 0.88 | PARP1 (0.82) | PARP1TNKSPARP6PARP15PARP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029551-B1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | MSD ITALIA SRL (IT) | 2018-10-31 | — | — | EP | claimed |
| EP-2029551-A2 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007138351-A2 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-12-06 | — | — | WO | disclosed |