Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 4/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 3/20 | 0.44 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10091934 | 1.00 | AKT2 (0.53) | AKT2PDPK1NTRK1NTRK2MET | |
| SCHEMBL14073768 | 0.90 | NTRK2 (0.53) | AKT2PDPK1NTRK1NTRK2NTRK3 | |
| SCHEMBL396734 | 0.90 | AKT2 (0.60) | AKT2PDPK1NTRK1NTRK2MET | |
| SCHEMBL10091935 | 0.90 | AKT2 (0.60) | AKT2PDPK1NTRK1NTRK2MET | |
| SCHEMBL10091933 | 0.88 | AKT2 (0.52) | AKT2PDPK1NTRK1NTRK2KDR | |
| SCHEMBL396456 | 0.88 | AKT2 (0.52) | AKT2PDPK1NTRK1NTRK2KDR | |
| SCHEMBL398703 | 0.84 | KDR (0.53) | AKT2NTRK1NTRK2KDRFLT3 | |
| SCHEMBL398702 | 0.84 | KDR (0.53) | AKT2NTRK1NTRK2KDRFLT3 | |
| SCHEMBL396921 | 0.84 | NTRK2 (0.52) | AKT2NTRK1NTRK2KDRFLT3 | |
| SCHEMBL10091939 | 0.84 | NTRK2 (0.52) | AKT2NTRK1NTRK2KDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101608-B2 | 3-(4-Methyl-imidazol-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide; including benign and malignant proliferative disorders as well as diseases resulting from inappropriate activation of the immune and nervous systems | IRM LLC, a Delware Limited Corporation (BM) | 2012-01-24 | — | — | US | claimed |
| US-8101608-B2 | 3-(4-Methyl-imidazol-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide; including benign and malignant proliferative disorders as well as diseases resulting from inappropriate activation of the immune and nervous systems | IRM LLC, a Delware Limited Corporation (BM) | 2012-01-24 | — | — | US | disclosed |