Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.46 |
| ▸ | SI | P14410 | 1/20 | 0.46 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PPID | Q08752 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3830166 | 0.84 | GAA (0.50) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL30560018 | 0.82 | GAA (0.48) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL30560019 | 0.82 | GAA (0.48) | GAAMGAMSIMGAM2ALDH1A1 | |
| Water SCHEMBL9038659 | 0.81 | GAA (0.46) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL6922121 | 0.81 | GAA (0.46) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL28033031 | 0.80 | GAA (0.50) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL11659340 | 0.79 | GAA (0.45) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL391332 | 0.79 | GAA (0.65) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL15391903 | 0.78 | GAA (0.48) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL7441120 | 0.77 | GAA (0.46) | GAAMGAMSIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064191-A1 | ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-2061771-A1 | ASPARTYL PROTEASE INHIBITORS CONTAINING A TRICYCLIC RING SYSTEM | SCHERING CORPORATION (US) | 2009-05-27 | — | — | EP | disclosed |
| EP-2032542-A2 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION (US) | 2009-03-11 | — | — | EP | disclosed |
| WO-2008073370-A1 | ASPARTYL PROTEASE INHIBITORS CONTAINING A TRICYCLIC RING SYSTEM | SCHERING CORPORATION (US) | 2008-06-19 | — | — | WO | disclosed |
| WO-2008073365-A1 | ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION (US) | 2008-06-19 | — | — | WO | disclosed |
| EP-1902057-A1 | MACROCYCLIC HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION (US) | 2008-03-26 | — | — | EP | disclosed |
| EP-1896478-A2 | ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007146225-A2 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2006138195-A1 | MACROCYCLIC HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION (US) | 2006-12-28 | — | — | WO | disclosed |
| WO-2006138264-A2 | ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION (US) | 2006-12-28 | — | — | WO | disclosed |