Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 14/20 | 0.74 |
| ▸ | RAD52 | P43351 | 1/20 | 0.73 |
| ▸ | TTK | P33981 | 1/20 | 0.64 |
| ▸ | BRD4 | O60885 | 7/20 | 0.64 |
| ▸ | BRDT | Q58F21 | 5/20 | 0.64 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.62 |
| ▸ | TAF1 | P21675 | 2/20 | 0.58 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13846150 | 0.92 | PLK1 (0.64) | PLK1RAD52TTKBRD4BRDT | |
| SCHEMBL1203323 | 0.90 | PLK1 (0.76) | PLK1RAD52TTKBRD4BRDT | |
| SCHEMBL21755686 | 0.88 | BRD4 (0.64) | PLK1RAD52TTKBRD4BRDT | |
| SCHEMBL3988414 | 0.87 | PLK1 (0.83) | PLK1RAD52BRD4BRDTALK | |
| SCHEMBL1202827 | 0.87 | PLK1 (0.83) | PLK1RAD52BRD4BRDTALK | |
| SCHEMBL4104990 | 0.87 | PLK1 (0.70) | PLK1RAD52TTKBRD4BRDT | |
| SCHEMBL1204198 | 0.86 | PLK1 (0.82) | PLK1RAD52BRD4BRDTALK | |
| SCHEMBL1204350 | 0.86 | PLK1 (0.82) | PLK1RAD52BRD4BRDTALK | |
| SCHEMBL1203489 | 0.86 | PLK1 (0.70) | PLK1RAD52TTKBRD4BRDT | |
| SCHEMBL1203973 | 0.86 | PLK1 (0.75) | PLK1RAD52BRD4BRDTALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090291938-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-26 | — | — | US | claimed |
| WO-2009067547-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-05-28 | — | — | WO | claimed |
| US-20090291938-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-26 | — | — | US | disclosed |
| US-20090291938-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-26 | — | — | US | disclosed |
| US-20090291938-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-26 | — | — | US | disclosed |
| WO-2009067547-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-05-28 | — | — | WO | disclosed |
| WO-2009067547-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291938-A1 | POLO-LIKE KINASE INHIBITORS | PLK1, PLK2, POLK | PLK1 1/4885RAD52 1250/4885TTK 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.