⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12307012 | 0.78 | MAPT (0.61) | — | |
| SCHEMBL14461124 | 0.78 | MAPT (0.61) | — | |
| SCHEMBL183148 | 0.74 | — | — | |
| SCHEMBL8291119 | 0.74 | — | — | |
| 5-Methylfurfural SCHEMBL51606 | 0.74 | — | — | |
| SCHEMBL7349983 | 0.73 | — | — | |
| SCHEMBL10920917 | 0.73 | — | — | |
| Ethylene Glycol SCHEMBL15556054 | 0.73 | MAPT (0.57) | — | |
| SCHEMBL12307010 | 0.72 | — | — | |
| SCHEMBL3723021 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968581-A4 | TETRACYCLIC KINASE INHIBITORS | GENENTECH INC (US) | 2009-05-27 | — | — | EP | claimed |
| US-20090131407-A1 | TETRACYCLIC KINASE INHIBITORS | GENENTECH, INC. | 2009-05-21 | — | — | US | claimed |
| EP-1968581-A2 | TETRACYCLIC KINASE INHIBITORS | Genentech, Inc. (US) | 2008-09-17 | — | — | EP | claimed |
| WO-2007120333-A2 | TETRACYCLIC KINASE INHIBITORS | GENENTECH, INC. (US) | 2007-10-25 | — | — | WO | claimed |
| EP-1968581-A4 | TETRACYCLIC KINASE INHIBITORS | GENENTECH INC (US) | 2009-05-27 | — | — | EP | disclosed |
| US-20090131407-A1 | TETRACYCLIC KINASE INHIBITORS | GENENTECH, INC. | 2009-05-21 | — | — | US | disclosed |
| EP-1968581-A2 | TETRACYCLIC KINASE INHIBITORS | Genentech, Inc. (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007120333-A2 | TETRACYCLIC KINASE INHIBITORS | GENENTECH, INC. (US) | 2007-10-25 | — | — | WO | disclosed |