Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 20/20 | 0.67 |
| ▸ | CDK2 | P24941 | 20/20 | 0.67 |
| ▸ | KDR | P35968 | 18/20 | 0.67 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.62 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.62 |
| ▸ | CDK4 | P11802 | 4/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.45 |
| ▸ | CCND1 | P24385 | 2/20 | 0.45 |
| ▸ | CDK9 | P50750 | 2/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
| ▸ | CCNH | P51946 | 1/20 | 0.45 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.45 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3989327 | 0.88 | CDK1 (0.67) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL3988091 | 0.85 | CDK1 (0.71) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL14112842 | 0.84 | CDK1 (0.78) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL14140889 | 0.82 | CDK1 (0.75) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL3983837 | 0.81 | CDK1 (0.67) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL3984790 | 0.81 | CDK1 (0.58) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL4580255 | 0.81 | CDK1 (0.74) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL3931191 | 0.81 | CDK1 (1.00) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL3989325 | 0.80 | CDK1 (0.70) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL14112802 | 0.80 | CDK1 (0.72) | CDK1CDK2KDRCCNB1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059511-A1 | SULPHOXIMIDES AS PROTEIN KINASE INHIBITORS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008025556-A1 | SULPHOXIMIDES AS PROTEIN KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-06 | — | — | WO | disclosed |