Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.74 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.45 |
| ▸ | AGPAT2 | O15120 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLA1 | P09884 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31484102 | 0.82 | MAPT (0.55) | MAPTPOLBGAAALOX5ABCG2 | |
| SCHEMBL6977133 | 0.81 | MAPT (0.57) | MAPTALOX5ABCG2NPC1RAB9A | |
| SCHEMBL13326018 | 0.80 | MAPT (0.59) | MAPTGAASMN1; SMN2ALOX5ABCG2 | |
| SCHEMBL30574121 | 0.79 | MAPT (0.62) | MAPTALOX5 | |
| SCHEMBL30306470 | 0.77 | BRD4 (0.57) | MAPTPOLBGAASMN1; SMN2ABCG2 | |
| SCHEMBL855547 | 0.77 | MAPT (0.48) | MAPTPOLBGAASMN1; SMN2NPC1 | |
| SCHEMBL17526103 | 0.77 | BRD4 (0.57) | MAPTPOLBGAASMN1; SMN2ABCG2 | |
| SCHEMBL6352558 | 0.76 | POLA1 (0.71) | MAPTPOLBGAASMN1; SMN2AGPAT2 | |
| SCHEMBL9870182 | 0.76 | MAPT (0.49) | MAPTPOLBGAASMN1; SMN2AGPAT2 | |
| SCHEMBL19690974 | 0.75 | MAPT (0.52) | MAPTPOLBGAASMN1; SMN2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | disclosed |