Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | DRD1 | P21728 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | DRD5 | P21918 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6260918 | 0.88 | CNR1 (0.64) | POLBKDM4ETDP1CNR1CNR2 | |
| SCHEMBL6763629 | 0.86 | POLB (0.63) | POLBKDM4ETDP1DRD1DRD4 | |
| SCHEMBL4551015 | 0.83 | POLB (0.53) | POLBKDM4ETDP1DRD1DRD4 | |
| SCHEMBL5319656 | 0.81 | KDM4E (0.70) | POLBKDM4ETDP1DRD1DRD4 | |
| SCHEMBL14578233 | 0.81 | DRD1 (0.65) | POLBKDM4ETDP1DRD1DRD4 | |
| Ammonia Solution, Strong SCHEMBL4267670 | 0.80 | KDM4E (0.68) | POLBKDM4ETDP1DRD1DRD4 | |
| SCHEMBL6042440 | 0.80 | POLB (0.68) | POLBKDM4ETDP1DRD1DRD4 | |
| SCHEMBL4224048 | 0.79 | DRD1 (0.63) | POLBKDM4EDRD1DRD4DRD5 | |
| SCHEMBL14396561 | 0.79 | POLB (0.63) | POLBKDM4EDRD1DRD4DRD5 | |
| SCHEMBL1853220 | 0.79 | DRD1 (0.62) | POLBKDM4EDRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035436-A1 | FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma S.A. (BE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2008001076-A1 | FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2008-01-03 | — | — | WO | disclosed |