Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 19/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.63 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.63 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4121632 | 0.86 | MTOR (0.64) | MTORPIK3CAPIK3CG | |
| SCHEMBL4114696 | 0.84 | MTOR (0.70) | MTORPIK3CAPIK3CG | |
| SCHEMBL3989252 | 0.83 | MTOR (0.70) | MTORPIK3CAPIK3CG | |
| SCHEMBL32914 | 0.79 | PIK3CA (0.94) | MTORPIK3CAPIK3CG | |
| SCHEMBL3994422 | 0.79 | PIK3CA (0.58) | MTORPIK3CAPIK3CG | |
| SCHEMBL32323 | 0.78 | PIK3CA (0.93) | MTORPIK3CAPIK3CG | |
| SCHEMBL32264 | 0.78 | PIK3CA (1.00) | MTORPIK3CAPIK3CG | |
| SCHEMBL3989822 | 0.78 | MTOR (0.68) | MTORPIK3CAPIK3CG | |
| SCHEMBL32681 | 0.78 | PIK3CA (0.81) | MTORPIK3CAPIK3CG | |
| Hydrochloric Acid SCHEMBL2520115 | 0.77 | PIK3CA (0.98) | MTORPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090149458-A1 | PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS | WYETH (US) | 2009-06-11 | — | — | US | claimed |
| WO-2009070524-A1 | PYRROLO[3,2-D]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND MTOR KINASE INHIBITORS | WYETH (US) | 2009-06-04 | — | — | WO | claimed |
| US-20090149458-A1 | PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS | WYETH (US) | 2009-06-11 | — | — | US | disclosed |
| WO-2009070524-A1 | PYRROLO[3,2-D]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND MTOR KINASE INHIBITORS | WYETH (US) | 2009-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149458-A1 | PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS | MTOR, PIK3CA, PIK3CD | MTOR 1/4885PIK3CA 2/4885PIK3CG 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.