Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.61 |
| ▸ | MTOR | P42345 | 10/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.53 |
| ▸ | SGK1 | O00141 | 2/20 | 0.52 |
| ▸ | SYK | P43405 | 2/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.49 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3989077 | 0.80 | SGK1 (0.57) | PIK3CAMTORPIK3CGSGK1SYK | |
| SCHEMBL4556151 | 0.80 | PIK3CA (0.60) | PIK3CAMTORPIK3CGAURKBPIK3CD | |
| SCHEMBL3991785 | 0.78 | PIK3CA (0.71) | PIK3CAMTORPIK3CGPIK3CDPRKDC | |
| SCHEMBL1311008 | 0.77 | PIK3CA (0.58) | PIK3CAMTORPIK3CGPIK3CDCYP2C9 | |
| SCHEMBL4995644 | 0.77 | PIK3CA (0.85) | PIK3CAMTORPIK3CGAURKB | |
| SCHEMBL1311087 | 0.77 | PIK3CA (0.59) | PIK3CAMTORPIK3CGAURKBPIK3CD | |
| SCHEMBL4995646 | 0.76 | PIK3CA (1.00) | PIK3CAMTORPIK3CGAURKBGRIA1 | |
| SCHEMBL13828581 | 0.76 | PIK3CA (0.56) | PIK3CAMTORPIK3CGAURKBCYP2C9 | |
| SCHEMBL3988835 | 0.76 | PIK3CA (1.00) | PIK3CAMTORPIK3CGAURKB | |
| SCHEMBL3993271 | 0.76 | PIK3CA (0.84) | PIK3CAMTORPIK3CGAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078021-A2 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-07-15 | — | — | EP | claimed |
| WO-2008115974-A2 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2008-09-25 | — | — | WO | claimed |
| US-20080234262-A1 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2008-09-25 | — | — | US | claimed |
| US-20080234262-A1 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234262-A1 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | MTOR, PIK3CA, PDPK1 | PIK3CA 2/4885MTOR 1/4885PIK3CG 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.