Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 14/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.34 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.34 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.34 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.34 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.34 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3995270 | 0.89 | TLR8 (0.60) | TLR8TLR7CSNK1A1CSNK1DPRKCD | |
| SCHEMBL3992937 | 0.86 | TLR8 (0.54) | TLR8TLR7CSNK1A1CSNK1DPRKCD | |
| SCHEMBL3998127 | 0.86 | TLR8 (0.54) | TLR8TLR7 | |
| SCHEMBL5571999 | 0.85 | TLR8 (0.54) | TLR8TLR7CSNK1A1CSNK1DPRKCD | |
| Hydrochloric Acid SCHEMBL3995835 | 0.84 | TLR8 (0.53) | TLR8TLR7CSNK1A1CSNK1DPRKCD | |
| SCHEMBL3993985 | 0.84 | TLR8 (0.51) | TLR8TLR7CSNK1A1CSNK1DPRKCD | |
| SCHEMBL3993609 | 0.84 | TLR8 (0.57) | TLR8TLR7ADORA3ADORA2AADORA2B | |
| SCHEMBL3998067 | 0.83 | TLR8 (0.50) | TLR8TLR7CSNK1A1CSNK1DPRKCD | |
| SCHEMBL3996104 | 0.82 | TLR7 (0.57) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL3991821 | 0.82 | TLR8 (0.53) | TLR8TLR7ADORA3ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696912-A4 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | 3M INNOVATIVE PROPERTIES CO (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-1696912-A2 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | 3M Innovative Properties Company (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005079195-A2 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2005-09-01 | — | — | WO | disclosed |