Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3997966 | 0.84 | SSTR5 (0.44) | SSTR5KDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3999698 | 0.82 | SSTR5 (0.45) | SSTR5TSHRHTTMAPK1KDM4E | |
| SCHEMBL3998650 | 0.81 | SSTR5 (0.47) | SSTR5TSHRHTTMAPK1KDM4E | |
| SCHEMBL1877555 | 0.79 | SSTR5 (0.57) | SSTR5HRH1HTR2B | |
| SCHEMBL1878817 | 0.79 | SSTR5 (0.46) | SSTR5HTTHRH1HTR2B | |
| SCHEMBL4001646 | 0.77 | KDM4E (0.43) | SSTR5TSHRHTTMAPK1KDM4E | |
| SCHEMBL4001649 | 0.74 | SSTR5 (0.50) | SSTR5TSHRHTTMAPK1KDM4E | |
| SCHEMBL4002203 | 0.74 | SSTR5 (0.53) | SSTR5ALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL3997523 | 0.72 | SSTR5 (0.45) | SSTR5MAPK1KDM4EALDH1A1KMT2A | |
| SCHEMBL1877068 | 0.72 | SSTR5 (0.56) | SSTR5HRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066658-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-06-10 | — | — | EP | claimed |
| WO-2008031735-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-20 | — | — | WO | claimed |