Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 19/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3996125 | 1.00 | HRH4 (0.59) | HRH4HRH3GRM1 | |
| SCHEMBL3195553 | 0.85 | MAP4K4 (0.53) | HRH4HRH3 | |
| SCHEMBL3200673 | 0.85 | MAP4K4 (0.53) | HRH4HRH3 | |
| SCHEMBL3209109 | 0.84 | MAP4K4 (0.52) | HRH4HRH3 | |
| SCHEMBL3998706 | 0.76 | HRH4 (0.49) | HRH4HRH3 | |
| SCHEMBL3199644 | 0.76 | HRH4 (0.71) | HRH4HRH3 | |
| SCHEMBL3197463 | 0.75 | HRH4 (0.46) | HRH4HRH3 | |
| SCHEMBL3203009 | 0.75 | HRH4 (0.46) | HRH4HRH3 | |
| SCHEMBL3207707 | 0.75 | HRH4 (0.67) | HRH4HRH3 | |
| SCHEMBL3207716 | 0.75 | HRH4 (0.67) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066645-A2 | 2 AMINO-PYRIMIDINE DERIVATIVES AS H4 RECEPTOR ANTAGONISTS, PROCESSES FOR PREPARING THEM AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS | UCB Pharma S.A. (BE) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008031556-A2 | 2 AMINO-PYRIMIDINE DERIVATIVES AS H4 RECEPTOR ANTAGONISTS, PROCESSES FOR PREPARING THEM AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS | UCB PHARMA, S.A. (BE) | 2008-03-20 | — | — | WO | disclosed |