Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 9/20 | 0.51 |
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | DRD4 | P21917 | 5/20 | 0.44 |
| ▸ | DRD3 | P35462 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | GMNN | O75496 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4001649 | 0.93 | SSTR5 (0.50) | SSTR5DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL3999701 | 0.84 | SSTR5 (0.53) | SSTR5ALDH1A1LMNAHRH1HTR2B | |
| SCHEMBL4002203 | 0.83 | SSTR5 (0.53) | SSTR5DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL4003114 | 0.81 | SSTR5 (0.50) | SSTR5ALDH1A1LMNAHRH1HTR2B | |
| SCHEMBL1876374 | 0.78 | SSTR5 (0.67) | SSTR5DRD2DRD4DRD3HRH1 | |
| SCHEMBL1880245 | 0.77 | SSTR5 (0.54) | SSTR5HRH1HTR2BAPP | |
| SCHEMBL3995690 | 0.76 | SSTR5 (0.43) | SSTR5DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL3998650 | 0.73 | SSTR5 (0.47) | SSTR5DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL4000500 | 0.72 | APP (0.40) | SSTR5ALDH1A1LMNAHRH1HTR2B | |
| Hydrochloric Acid SCHEMBL4224965 | 0.71 | SSTR5 (0.48) | SSTR5DRD2DRD4DRD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066658-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-06-10 | — | — | EP | claimed |
| WO-2008031735-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-20 | — | — | WO | claimed |