Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.80 |
| ▸ | MAPT | P10636 | 7/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL399995 | 1.00 | HTT (0.80) | HTTMAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL399066 | 0.89 | HTT (1.00) | HTTMAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL399065 | 0.89 | HTT (1.00) | HTTMAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL14457011 | 0.86 | HTT (0.58) | HTTMAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL399883 | 0.82 | HTT (0.71) | HTTMAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL399884 | 0.82 | HTT (0.71) | HTTMAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8713370 | 0.77 | MAPT (0.66) | HTTMAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8713366 | 0.77 | MAPT (0.66) | HTTMAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL10148248 | 0.73 | CYP19A1 (0.47) | HTTMAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8717977 | 0.71 | MAPT (0.64) | HTTMAPTALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101604-B2 | Alpha carbolines and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-20100311715-A1 | ALPHA CARBOLINES AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-12-09 | — | — | US | disclosed |
| US-7812018-B2 | inhibitors of I kappa B kinase ( IKK-2) 2-amino-9-methyl-9H-pyrido[2,3-b]indole-3-carboxamide, useful for treating inflammatory diseases and cancer | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |
| US-20070207997-A1 | Alpha carbolines and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2007-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070207997-A1 | Alpha carbolines and uses thereof | CHRM1, CNR1, CXCR1 | HTT 1666/4885MAPT 3493/4885ALDH1A1 416/4885 |
| US-20100311715-A1 | ALPHA CARBOLINES AND USES THEREOF | CHRM1, CNR1, CXCR1 | HTT 1666/4885MAPT 3493/4885ALDH1A1 416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.