Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL398433 | 0.83 | KDM4E (0.53) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL3443305 | 0.83 | KDM4E (0.53) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL401059 | 0.79 | KDM4E (0.57) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL400462 | 0.78 | KDM4E (0.50) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL397629 | 0.78 | KDM4E (0.56) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL399931 | 0.77 | KDM4E (0.55) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL14457086 | 0.74 | KDM4E (0.46) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL398445 | 0.73 | KDM4E (0.74) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL399576 | 0.73 | KDM4E (0.38) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL399320 | 0.72 | KDM4E (0.44) | KDM4EALDH1A1GAAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101604-B2 | Alpha carbolines and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-01-24 | — | — | US | disclosed |