Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 13/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.55 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.39 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.39 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.39 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4203898 | 0.94 | MTOR (0.62) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4200189 | 0.93 | MTOR (0.63) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4204103 | 0.91 | PIK3CA (0.53) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3932807 | 0.90 | PIK3CA (0.54) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4208764 | 0.88 | PIK3CA (0.55) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3924153 | 0.88 | PIK3CA (0.55) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4203754 | 0.88 | PIK3CA (0.59) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4200493 | 0.87 | PIK3CA (0.60) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4197795 | 0.85 | PIK3CA (0.53) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3929293 | 0.84 | MTOR (0.64) | MTORPIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074118-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | AstraZeneca AB (SE) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |