Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | FABP4 | P15090 | 1/20 | 0.64 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31023418 | 1.00 | TSHR (0.73) | TSHRKDM4EFABP4SLC2A1MEN1 | |
| SCHEMBL20219039 | 0.88 | TSHR (0.76) | TSHRKDM4EFABP4SLC2A1MEN1 | |
| SCHEMBL9775876 | 0.87 | TSHR (0.69) | TSHRKDM4EFABP4SLC2A1MEN1 | |
| SCHEMBL29678256 | 0.86 | TSHR (0.59) | TSHRKDM4EMEN1KMT2AHPGD | |
| SCHEMBL242212 | 0.86 | TSHR (0.59) | TSHRKDM4EMEN1KMT2AHPGD | |
| SCHEMBL10032004 | 0.85 | TSHR (0.71) | TSHRKDM4EFABP4SLC2A1MEN1 | |
| SCHEMBL15302068 | 0.85 | TSHR (1.00) | TSHRKDM4EFABP4SLC2A1MEN1 | |
| SCHEMBL27833985 | 0.85 | TSHR (0.71) | TSHRKDM4EFABP4SLC2A1MEN1 | |
| SCHEMBL7933287 | 0.85 | TSHR (0.71) | TSHRKDM4EFABP4SLC2A1MEN1 | |
| SCHEMBL23540894 | 0.84 | TSHR (0.66) | TSHRKDM4EFABP4SLC2A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110903253-B | Quinazolinone compound and preparation method and application thereof | 西安交通大学医学院第一附属医院 | 2020-12-25 | — | — | CN | claimed |
| CN-111056978-A | Sulfonamide compound and preparation method and application thereof | 西安交通大学 | 2020-04-24 | — | — | CN | claimed |
| CN-110903253-A | Quinazolinone compound and preparation method and application thereof | 西安交通大学医学院第一附属医院 | 2020-03-24 | — | — | CN | claimed |
| CN-101921587-A | A kind of fluorescent probe and preparation method thereof with tumor cell proliferation inhibition activity | UNIV XI AN JIAOTONG | 2010-12-22 | — | — | CN | claimed |
| CN-101638391-A | 2-[(substituted aminobenzene)carbonylmethylthio]-6-(2,6-dichlorobenzyl)-3H-pyrimidyl-4-ketone derivative and preparation method and application thereof | UNIV SHANDONG | 2010-02-03 | — | — | CN | claimed |
| CN-118126030-A | Preparation method of pyrazoline-1, 3, 4-oxadiazole thioacetamide derivative and application of pyrazoline-1, 3, 4-oxadiazole thioacetamide derivative as pesticide | 贵州大学 | 2024-06-04 | — | — | CN | disclosed |
| WO-2021028919-A1 | METHODS AND COMPOSITIONS FOR PREVENTING SKIN TOXICITIES CAUSED BY BIOLOGICAL TARGETED CANCER DRUGS | HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED (IL) | 2021-02-18 | — | — | WO | disclosed |
| CN-111056978-B | Sulfonamide compound and preparation method and application thereof | 西安交通大学 | 2021-01-19 | — | — | CN | disclosed |
| CN-110903253-B | Quinazolinone compound and preparation method and application thereof | 西安交通大学医学院第一附属医院 | 2020-12-25 | — | — | CN | disclosed |
| CN-111056978-A | Sulfonamide compound and preparation method and application thereof | 西安交通大学 | 2020-04-24 | — | — | CN | disclosed |
| CN-110903253-A | Quinazolinone compound and preparation method and application thereof | 西安交通大学医学院第一附属医院 | 2020-03-24 | — | — | CN | disclosed |
| CN-102358731-B | 2-substituted-6, 7-dimethoxy tetrahydroisoquinoline derivative, preparation method thereof, pharmaceutical composition and application thereof | ZHONGSHAN BOWEN MEDICAL TECHNOLOGY CO LTD | 2013-01-02 | — | — | CN | disclosed |
| EP-0208510-A2 | 1-Substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents | PFIZER INC. (US) | 1987-01-14 | — | — | EP | disclosed |
| CN-86105309-A | Oxindole-3-carbonyl amines the compound that replaces as the 1-of anti-inflammatory and anodyne | — | 1987-01-14 | — | — | CN | disclosed |
| EP-0175551-A1 | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds | PFIZER INC. (US) | 1986-03-26 | — | — | EP | disclosed |
| US-4569942-A | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents | PFIZER INC. (US) | 1986-02-11 | — | — | US | disclosed |
| EP-0164860-A1 | N,3-disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents | PFIZER INC. (US) | 1985-12-18 | — | — | EP | disclosed |
| US-4556672-A | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents | PFIZER INC. (US) | 1985-12-03 | — | — | US | disclosed |
| EP-0156603-A2 | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents | PFIZER INC. (US) | 1985-10-02 | — | — | EP | disclosed |
| EP-0153818-A2 | 1,3-Disubstituted 2-oxindoles as analgesic and anti-inflammatory agents | PFIZER INC. (US) | 1985-09-04 | — | — | EP | disclosed |