Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 10/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3996425 | 0.89 | TSHR (0.49) | LMNAHPGDKMT2ATSHRNPC1 | |
| SCHEMBL3752062 | 0.85 | HPGD (0.47) | LMNAHPGDMAPK1KMT2ATSHR | |
| SCHEMBL3765786 | 0.84 | HPGD (0.46) | LMNAHPGDMAPK1KMT2ATSHR | |
| SCHEMBL3759329 | 0.83 | HPGD (0.44) | LMNAHPGDMAPK1KMT2ATSHR | |
| SCHEMBL3764989 | 0.82 | SMN1; SMN2 (0.44) | LMNAHPGDMAPK1KMT2ATSHR | |
| SCHEMBL3751655 | 0.81 | KMT2A (0.45) | LMNAHPGDMAPK1KMT2ATSHR | |
| SCHEMBL3754775 | 0.80 | KMT2A (0.44) | LMNAHPGDMAPK1KMT2ATSHR | |
| SCHEMBL3763874 | 0.80 | KMT2A (0.44) | LMNAHPGDMAPK1KMT2ATSHR | |
| SCHEMBL3760043 | 0.79 | SMN1; SMN2 (0.44) | HPGDMAPK1KMT2ATSHRRECQL | |
| SCHEMBL3758808 | 0.76 | TSHR (0.50) | LMNAHPGDMAPK1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071895-A1 | FUSED THIAZOLE AND THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2009-06-11 | — | — | WO | disclosed |