Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.79 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4003895 | 1.00 | EPHX2 (0.79) | EPHX2TSHRALDH1A1RAB9ALMNA | |
| SCHEMBL612254 | 0.87 | EPHX2 (0.68) | EPHX2TSHRALDH1A1RAB9ALMNA | |
| SCHEMBL4963147 | 0.87 | EPHX2 (0.68) | EPHX2TSHRALDH1A1RAB9ALMNA | |
| SCHEMBL612253 | 0.87 | EPHX2 (0.68) | EPHX2TSHRALDH1A1RAB9ALMNA | |
| SCHEMBL4006092 | 0.86 | TSHR (0.90) | EPHX2TSHRALDH1A1RAB9ALMNA | |
| SCHEMBL4006097 | 0.86 | TSHR (0.90) | EPHX2TSHRALDH1A1RAB9ALMNA | |
| SCHEMBL4007567 | 0.85 | TSHR (0.70) | EPHX2TSHRRAB9AKMT2AMEN1 | |
| SCHEMBL4004305 | 0.85 | KMT2A (0.80) | EPHX2TSHRLMNAPOLBSMN1; SMN2 | |
| SCHEMBL4007562 | 0.85 | TSHR (0.70) | EPHX2TSHRRAB9AKMT2AMEN1 | |
| SCHEMBL4004312 | 0.85 | KMT2A (0.80) | EPHX2TSHRLMNAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |