Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 19/20 | 0.62 |
| ▸ | CCNE2 | O96020 | 8/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.54 |
| ▸ | CDK2 | P24941 | 8/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.52 |
| ▸ | MUSK | O15146 | 1/20 | 0.52 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | FES | P07332 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1269921 | 1.00 | IGF1R (0.62) | IGF1RCCNE2CCNE1CDK2PLK4 | |
| SCHEMBL15810121 | 0.96 | IGF1R (0.67) | IGF1RCCNE2CCNE1CDK2PLK4 | |
| SCHEMBL1269506 | 0.91 | IGF1R (0.59) | IGF1RCCNE2CCNE1CDK2PLK4 | |
| SCHEMBL1269762 | 0.91 | IGF1R (0.60) | IGF1RCCNE2CCNE1CDK2PLK4 | |
| SCHEMBL15810248 | 0.91 | IGF1R (0.58) | IGF1RCCNE2CCNE1CDK2PLK4 | |
| SCHEMBL1268874 | 0.90 | IGF1R (0.59) | IGF1RCCNE2CCNE1CDK2PLK4 | |
| SCHEMBL1269803 | 0.90 | IGF1R (0.69) | IGF1RCCNE2CCNE1CDK2PLK4 | |
| SCHEMBL1270148 | 0.89 | IGF1R (0.59) | IGF1RCCNE2CCNE1CDK2PLK4 | |
| SCHEMBL1268869 | 0.88 | IGF1R (0.70) | IGF1RCCNE2CCNE1CDK2PLK4 | |
| SCHEMBL1269888 | 0.88 | IGF1R (0.59) | IGF1RCCNE2CCNE1CDK2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041138-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | Brystol-Myers Squibb Company (US) | 2009-04-01 | — | — | EP | claimed |
| WO-2008005956-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-10 | — | — | WO | claimed |
| EP-2041138-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | Brystol-Myers Squibb Company (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008005956-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-10 | — | — | WO | disclosed |