Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | PNLIP | P16233 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4001431 | 0.76 | MEN1 (0.55) | NPC1TSHRRAB9AKMT2AKDM4E | |
| SCHEMBL11247603 | 0.76 | NPC1 (0.63) | POLBNPC1TSHRRAB9AKMT2A | |
| SCHEMBL4003989 | 0.75 | POLB (0.59) | POLBNPC1TSHRRAB9AKMT2A | |
| SCHEMBL13873725 | 0.74 | POLB (0.61) | POLBRAB9AKMT2AKDM4EALDH1A1 | |
| SCHEMBL4009843 | 0.74 | SMN1; SMN2 (0.49) | NPC1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL10972474 | 0.70 | KMT2A (0.70) | POLBNPC1TSHRKMT2AKDM4E | |
| SCHEMBL10968923 | 0.70 | KMT2A (0.60) | POLBNPC1TSHRKMT2AKDM4E | |
| SCHEMBL4939060 | 0.70 | KMT2A (0.82) | POLBKMT2AKDM4EALDH1A1GAA | |
| SCHEMBL13754015 | 0.69 | POLB (0.68) | POLBNPC1TSHRRAB9AKMT2A | |
| SCHEMBL10969124 | 0.69 | P2RY1 (0.60) | POLBNPC1TSHRKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2068878-A2 | RHO KINASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2009-06-17 | — | — | EP | claimed |
| WO-2008036540-A2 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-03-27 | — | — | WO | claimed |