Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 14/20 | 0.64 |
| ▸ | JAK2 | O60674 | 3/20 | 0.57 |
| ▸ | JAK3 | P52333 | 2/20 | 0.57 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4005550 | 1.00 | NTRK1 (0.64) | NTRK1JAK2JAK3IGF1RNUAK1 | |
| SCHEMBL4438437 | 0.85 | JAK2 (0.76) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL4007328 | 0.85 | JAK2 (0.76) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL4160441 | 0.82 | NTRK1 (0.82) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL4073830 | 0.79 | NTRK1 (0.79) | NTRK1IGF1R | |
| SCHEMBL5029662 | 0.78 | NTRK1 (1.00) | NTRK1JAK2JAK3NUAK1 | |
| SCHEMBL4147228 | 0.77 | NTRK1 (1.00) | NTRK1IGF1R | |
| SCHEMBL4144068 | 0.77 | NTRK1 (1.00) | NTRK1IGF1R | |
| SCHEMBL3344106 | 0.77 | NTRK1 (0.75) | NTRK1JAK2IGF1R | |
| SCHEMBL3341087 | 0.77 | NTRK1 (0.75) | NTRK1JAK2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007753-A2 | 4- (3-AMINOPYRAZOLE) -PYRIMIDINE DERIVATIVEE AND THEIR USE AS TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |