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Lindane

Lindane

SCHEMBL4005859

Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H]1Cl.Oc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

823298382338688239847Rdl1Rdl2Rdl3

The experimentally established mechanism targets of Lindane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 6/20 0.71
▸ HPGD P15428 6/20 0.71
▸ HSD17B10 Q99714 6/20 0.71
▸ LMNA P02545 3/20 0.71
▸ MEN1 O00255 2/20 0.71
▸ ALDH1A1 P00352 2/20 0.71
▸ MAPT P10636 2/20 0.71
▸ KMT2A Q03164 2/20 0.71
▸ CYP1A2 P05177 4/20 0.43
▸ CYP2C9 P11712 4/20 0.43
▸ HIF1A Q16665 3/20 0.43
▸ CASP1 P29466 1/20 0.40
▸ CYP2C19 P33261 1/20 0.39
▸ MAPK1 P28482 3/20 0.37
▸ CYP3A4 P08684 5/20 0.36
▸ GABRA1 P14867 1/20 0.36
▸ GABRB1 P18505 1/20 0.36
▸ GABRG2 P18507 1/20 0.36
▸ GABRR1 P24046 1/20 0.36
▸ GABRB3 P28472 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lindane SCHEMBL18045555 0.91 TSHR (0.59) TSHRHPGDHSD17B10LMNAMEN1
Perchlorobenzene SCHEMBL28269084 0.84 HSD17B10 (1.00) TSHRHPGDHSD17B10LMNAMEN1
Pentachlorophenol SCHEMBL5315995 0.84 HSD17B10 (1.00) TSHRHPGDHSD17B10LMNAMEN1
Pentachlorophenol SCHEMBL1492 0.84 HSD17B10 (1.00) TSHRHPGDHSD17B10LMNAMEN1
Pentachlorophenol SCHEMBL1330735 0.84 HSD17B10 (1.00) TSHRHPGDHSD17B10LMNAMEN1
Pentachlorophenol SCHEMBL23121452 0.84 HSD17B10 (1.00) TSHRHPGDHSD17B10LMNAMEN1
Pentachlorophenol SCHEMBL21647360 0.81 HSD17B10 (0.91) TSHRHPGDHSD17B10LMNAMEN1
Pentachlorophenol SCHEMBL41162 0.81 HSD17B10 (0.91) TSHRHPGDHSD17B10LMNAMEN1
Pentachlorophenol SCHEMBL21177789 0.81 HSD17B10 (0.91) TSHRHPGDHSD17B10LMNAMEN1
Pentachlorophenol SCHEMBL22027593 0.81 HSD17B10 (0.91) TSHRHPGDHSD17B10LMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1984021-A4 VIABLE NON-TOXIC GRAM NEGATIVE BACTERIA UNIV MICHIGAN (US) 2009-06-24 — — EP disclosed
EP-1984021-A2 VIABLE NON-TOXIC GRAM NEGATIVE BACTERIA THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2008-10-29 — — EP disclosed
WO-2008083456-A1 MICROSATELLITE-BASED FINGERPRINTING SYSTEM FOR SACCHARUM COMPLEX CANAVIALIS S.A. (BR) 2008-07-17 — — WO disclosed
WO-2007084633-A2 VIABLE NON-TOXIC GRAM NEGATIVE BACTERIA THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2007-07-26 — — WO disclosed
US-6090762-A HAVING A STABILIZER COMPRISING A HYDROPHOBIC GROUP WITH FROM 5 TO 25 CARBON ATOMS LINKED AT ONE END TO ONE END OF AT LEAST ONE HYDROPHILIC GROUP OF GIVEN MASS, SAID STABILIZER BEING AN ALKYL THIOL CAPPED POLYACRYLATE WHICH INHIBITS FLOCCULATION ALBRIGHT & WILSON UK LIMITED (GB) 2000-07-18 — — US disclosed
US-4124534-A CUPRIC CHLORIDE, POTASSIUM CHLORIDE, CALCIUM CHLORIDE, MAGNESIUM CHLORIDE DIAMOND SHAMROCK CORPORATION (US) 1978-11-07 — — US disclosed
US-4052221-A CHLORINATED NAPTHALENE, PARATERPHENYL, SEMICONDUCTOR WAFER WESTERN ELECTRIC COMPANY, INC. (US) 1977-10-04 — — US disclosed
US-3970494-A Method for adhering one surface to another WESTERN ELECTRIC CO., INC. (US) 1976-07-20 — — US disclosed