Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 10/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4006917 | 1.00 | EPHX2 (0.77) | EPHX2ALDH1A1LMNATSHRKMT2A | |
| SCHEMBL4155964 | 0.91 | EPHX2 (0.77) | EPHX2ALDH1A1LMNATSHRKMT2A | |
| SCHEMBL4004680 | 0.88 | KMT2A (0.87) | EPHX2ALDH1A1LMNATSHRKMT2A | |
| SCHEMBL4004803 | 0.88 | KMT2A (0.87) | EPHX2ALDH1A1LMNATSHRKMT2A | |
| SCHEMBL4006595 | 0.88 | KMT2A (0.68) | EPHX2ALDH1A1LMNATSHRKMT2A | |
| SCHEMBL4006602 | 0.88 | KMT2A (0.68) | EPHX2ALDH1A1LMNATSHRKMT2A | |
| SCHEMBL4004673 | 0.88 | KMT2A (0.87) | EPHX2ALDH1A1LMNATSHRKMT2A | |
| SCHEMBL4005679 | 0.88 | EPHX2 (0.76) | EPHX2ALDH1A1LMNATSHRKMT2A | |
| SCHEMBL4006513 | 0.88 | EPHX2 (0.78) | EPHX2ALDH1A1LMNATSHRKMT2A | |
| SCHEMBL4006092 | 0.88 | TSHR (0.90) | EPHX2ALDH1A1LMNATSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | claimed |