Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | TTK | P33981 | 4/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.39 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.38 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4008126 | 0.91 | NTRK1 (0.44) | NTRK1MAP2K4MAP2K7DYRK1AGPR17 | |
| SCHEMBL4015191 | 0.86 | NTRK1 (0.48) | NTRK1DYRK1APRKAG1PRKAA1PRKAB1 | |
| SCHEMBL4014470 | 0.85 | TTK (0.41) | TTKMAP2K4MAP2K7MAPK8GPR17 | |
| SCHEMBL4006597 | 0.84 | CSNK2A1 (0.52) | DYRK1AGPR17PRKAA1CSNK2A1WNT1 | |
| SCHEMBL4008249 | 0.82 | TTK (0.41) | TTKMAP2K4MAP2K7MAPK8GPR17 | |
| SCHEMBL4004563 | 0.82 | TTK (0.41) | TTKMAP2K4MAP2K7MAPK8GPR17 | |
| SCHEMBL4008264 | 0.82 | TTK (0.43) | TTKMAP2K4MAP2K7MAPK8GPR17 | |
| SCHEMBL4008113 | 0.81 | APEX1 (0.49) | NTRK1TTKMAPK8PRKAG1PRKAA1 | |
| SCHEMBL4004440 | 0.80 | TTK (0.52) | TTKMAP2K4MAP2K7MAPK8DYRK1A | |
| SCHEMBL4006373 | 0.79 | NTRK1 (0.41) | NTRK1TTKMAP2K4MAP2K7MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7473701-B2 | Substituted indazoles, compositions containing them, method of production and use | AVENTIS PHARMA S.A. (FR) | 2009-01-06 | — | — | US | disclosed |
| US-20050059722-A1 | Substituted indazoles, compositions containing them, method of production and use | AVENTIS PHARMA S.A. (FR) | 2005-03-17 | — | — | US | disclosed |
| US-6858638-B2 | Substituted indazoles, compositions containing them, method of production and use | AVENTIS PHARMA S.A. (FR) | 2005-02-22 | — | — | US | disclosed |
| US-20040106667-A1 | Substituted indazoles, compositions containing them, method of production and use | AVENTIS PHARMA S.A. (FR) | 2004-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106667-A1 | Substituted indazoles, compositions containing them, method of production and use | ABL1, CDK3, CILK1 | NTRK1 1342/4885TTK 215/4885MAP2K4 340/4885 |
| US-20050059722-A1 | Substituted indazoles, compositions containing them, method of production and use | ABL1, CDK3, CILK1 | NTRK1 1376/4885TTK 223/4885MAP2K4 328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.