Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 15/20 | 0.60 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4007714 | 0.81 | PTGES2 (0.60) | PTGES2CA12CA1CA2CA9 | |
| SCHEMBL4009405 | 0.81 | PTGES2 (0.62) | PTGES2CA1CA2 | |
| SCHEMBL4012566 | 0.77 | PTGES2 (0.63) | PTGES2CA12CA1CA2CA9 | |
| SCHEMBL4006541 | 0.77 | PTGES2 (0.63) | PTGES2CA12CA1CA2CA9 | |
| SCHEMBL3771845 | 0.75 | PTGES2 (1.00) | PTGES2CA1CA2 | |
| SCHEMBL3771839 | 0.75 | PTGES2 (1.00) | PTGES2CA1CA2 | |
| SCHEMBL3771842 | 0.75 | PTGES2 (1.00) | PTGES2CA1CA2 | |
| SCHEMBL4006017 | 0.72 | PTGES2 (0.63) | PTGES2CA12CA1CA2CA9 | |
| SCHEMBL3774357 | 0.64 | PTGES2 (1.00) | PTGES2 | |
| SCHEMBL3774354 | 0.64 | PTGES2 (1.00) | PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234993-A1 | BIS- (SULF ONYLAMINO) DERIVATIVES FOR USE IN THERAPY | AstraZeneca AB (SE) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009082347-A1 | BIS- (SULF ONYLAMINO) DERIVATIVES FOR USE IN THERAPY | ASTRAZENECA AB (SE) | 2009-07-02 | — | — | WO | disclosed |