Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 19/20 | 0.51 |
| ▸ | LIMK2 | P53671 | 19/20 | 0.51 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30595921 | 0.88 | LIMK1 (0.51) | LIMK1LIMK2TNK2 | |
| SCHEMBL30595935 | 0.88 | LIMK1 (0.59) | LIMK1LIMK2TNK2 | |
| SCHEMBL4008369 | 0.83 | LIMK1 (0.49) | LIMK1LIMK2 | |
| SCHEMBL15032875 | 0.83 | JAK2 (0.62) | LIMK1LIMK2 | |
| SCHEMBL27308974 | 0.81 | JAK1 (0.48) | LIMK1LIMK2TNK2 | |
| SCHEMBL30729891 | 0.81 | JAK1 (0.48) | LIMK1LIMK2TNK2 | |
| SCHEMBL30595923 | 0.81 | LIMK1 (0.64) | LIMK1LIMK2TNK2 | |
| SCHEMBL30595975 | 0.80 | JAK1 (0.58) | LIMK1LIMK2TNK2 | |
| SCHEMBL4006126 | 0.80 | JAK1 (0.58) | LIMK1LIMK2TNK2 | |
| SCHEMBL30595945 | 0.78 | TNK2 (0.47) | LIMK1LIMK2TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |